role of glycine in collagen

Storia. Glycine played a role in maintaining the health of mice suffering from osteoarthritis . Additionally, following a diet high in high quality protein and plant foods such as fruits and vegetables, which contain collagen-supportive and protective nutrients, may also help protect collagen stores and prevent collagen damage and loss (33). While some supplements may contain only one or two types of collagen, othercollagen productsmay offer a blend of several different types. Wu S., Li H., Yang H., Zhang X., Li Z., Xu S. Quantitative analysis on collagen morphology in aging skin based on multiphoton microscopy. Approximately one-third of collagen is composed of glycine, and collagen is crucial for forming connective tissue that keeps joints flexible and able to withstand shock. Proteins are made from amino acids. 2005-2022 Healthline Media a Red Ventures Company. Standard collagen sources are typically bovine, equine, avian or porcine in origin (Figure 2) [69]. To do so, four human genes that code for collagen are added to the genetic structure of these sources, which then generate their own collagen. Wenzel D., Schmidt A., Reimann K., Hescheler J., Pfitzer G., Bloch W., Fleischmann B.K. There are some reports that collagen supplements may cause other digestive side effects, such as heartburn and feelings of fullness (21). Which Vitamins, Minerals and Supplements Boost Your Immune System? Strengthens bones and joints. They differ by how the molecules are assembled, the cell components that are added and where the collagen is used in your body. In a 6-month study, 31 healthy adults took 16 grams of collagen daily. Vonbrunn E., Mueller M., Pichlsberger M., Sundl M., Helmer A., Wallner S.A., Rinner B., Tuca A.C., Kamolz L.P., Brislinger D., et al. They found that serotonin increased for only 10-20 minutes after glycine supplementation compared to more than 180 minutes after receiving a selective serotonin reuptake inhibitor (SSRI), an antidepressant medication. With its gel-like, smooth structure that covers and holds our bones together, collagen allows us to glide and move without pain. This process breaks down the protein into smaller pieces, making it easier for the body to absorb (20). Collagen supplementation provides a variety of health benefits. When you hydrolyze collagen, collagen peptides become bioavailable. More, Enoki Mushroom Benefits for Heart Health, Immunity & More, Antioxidant-Loaded Purple Potatoes: The Healthy, Versatile Carb. Hou A., Cohen B., Haimovic A., Elbuluk N. Microneedling: A Comprehensive Review. This article explains exactly how much protein you should eat. There are significant disadvantages associated with the use of animal-based collagen products including development of allergic reactions, transmission of prion diseases (e.g., bovine spongiform encephalopathy) and microbial contamination [70,71]. It's important to note that these were animal studies, and therefore the results may not apply in the same way to humans. J Am Heart Assoc. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. In other words, collagen fibrilsare what allow the shape of connective tissues to be defined and maintained. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Collagen plays an important role in providing structure, strength and support throughout your body. Additional challenges include precise tissue detailing (including development of structures like sweat glands and hair follicles) and the need for improved cross-linking techniques for structural control of the bioink-generated product [126]. A double-blind, placebo-controlled, randomized, clinical study on the effectiveness of collagen peptides for osteoarthritis demonstrated that collagen is a potential therapeutic agent as a nutritional supplements for the management of osteoarthritis and maintenance of joint health.. official website and that any information you provide is encrypted Only 22 alpha amino acids appear in the genetic code.. Amino acids can be classified according to the locations of the core structural functional Collagen (/ k l d n /) is the main structural protein in the extracellular matrix found in the body's various connective tissues.As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content. Strengthens bones and joints. Fisher G.J., Quan T., Purohit T., Shao Y., Cho M.K., He T., Varani J., Kang S., Voorhees J.J. Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Imbalances in the levels of these enzymes are a factor in wound chronicity. Wound repair and regeneration. If youre allergic to fish and fish collagen is used in the product, then obviously avoid. What Is Collagen, and What Is It Good For? Collagen consists of amino acids bound together to form a triple helix of elongated fibril It is most well-known for the structural role it plays in the body. Most of the published studies are based on in vitro or small animal models. Adding 1 2 tbsp a day to a breakfast smoothie will give you an additional 2.5 3.5g glycine per Tbls. Loss of mobility due to joint damage or stiffness. Collagen remodeling continues for months after wound closure and the tensile strength of the repaired tissue increases to about 8085% of normal tissue if all processes proceed without any perturbations [16]. will also be available for a limited time. We provide detailed revision materials for A-Level Biology students and teachers. Wounds infected with microbes that produce these collagen-degrading enzymes add to the imbalance, leading to chronic wounds. Collagen used for medical purposes comes from humans, cows, pigs or sheep. Ehterami A., Salehi M., Farzamfar S., Vaez A., Samadian H., Sahrapeyma H., Mirzaii M., Ghorbani S., Goodarzi A. Amino acids are the building blocks of proteins; therefore, it is no surprise that collagen is comprised of amino acids. Editor/authors are masked to the peer review process and editorial decision-making of their own work and are not able to access this work 8600 Rockville Pike Our Impact Factor has been continuously increasing over the past eleven years that I have been serving at the helm, and is now at 13.934, placing the journal amongst the top 4% of endocrinology, diabetes, and Have you ever felt like you have skeleton legs, the types that feel extra stiff and cause pain when you move? Effect of glycine: Studying memory and behavioral changes in mice. Despite claims to the contrary, there is little evidence that glycine supplements can prevent diabetes, relieve insomnia, heal wounds, treat an enlarged prostate, or reduce the risk of death from stroke. According to one randomized, triple-blind, placebo-controlled study, it also helps counteract the effects of aging and collagen loss, such aslooser skin, more wrinkles and less elasticity. Many of the studies conducted with supplements are funded by the supplement industry or the study authors have financial ties to the supplement industry. the research on collagen and its purported benefits was minimal or of poor quality. Supported by chaperone proteins, the pro-collagen triple-helical structure is stabilized for further processing and maturation in the Golgi apparatus and assembled into secretory vesicles that are extruded into the extracellular space where the pro-collagen is enzymatically modified into tropocollagen. Careers. Our Impact Factor has been continuously increasing over the past eleven years that I have been serving at the helm, and is now at 13.934, placing the journal amongst the top 4% of endocrinology, diabetes, and Shih B., Garside E., McGrouther D.A., Bayat A. Molecular dissection of abnormal wound healing processes resulting in keloid disease. A Pubmed search using the keywords collagen and wound healing lists >10,000 publications promoting various collagen formats as being ideal for wound-healing applications. Studies show that taking collagen supplements can support plump skin and may reduce wrinkles. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Key steps of the wound healing process, such as hemostasis, inflammation and angiogenesis are responsive to the ECM, collagen and its compounds [1,6,7,8,9,10,11,12,13]. Women experience a significant reduction in collagen production after menopause. However, depending on the ratio of mixtures in these blends, it may not be possible to clearly delineate the exact impact of the collagen component on the treatment outcomes. The complex macromolecules constituting the ECM include fibrous components (e.g., collagens and elastins) and glycoprotein components (e.g., fibronectin, proteoglycans and laminins). Collagen is the most abundant protein in the human body, making up approximately 25% to 35% of the whole body protein content. Zeltz C., Gullberg D. The integrincollagen connectionA glue for tissue repair? These supplements come primarily in powder form but are also available in capsules. Inflammation is a critical step in the normal process of wound healing and drives the proliferation of fibroblasts which synthesize collagen and ECM [9]. This makes it one of the best natural skin care ingredients available. Wear a wide-brimmed hat, sunglasses with UV protection and lightweight long-sleeved shirts and pants while outside. Type 1 collagen specifically accounts for almost 90 percent of the bodys supply, according to some findings. Natural composite dressings based on collagen, gelatin and plant bioactive compounds for wound healing: A review. Additionally, cosmetics companies use collagen in products like moisturizers and serums because of its moisturizing and humectant properties (9). Though collagens role in bone health is less well-known than its role in joint health, it nevertheless plays an important part in bone integrity. During this stage, collagen fragments serve as potent angiogenic signals to promote the development of new blood vessels. It accounts for about 30% of its total protein. Dietary fibers are diverse in chemical composition, and can be grouped generally by their solubility, viscosity, and fermentability, which affect how fibers are processed in the body. Gusev E, Skvortsova V, Dambinova S, et al. Marine collagen and its derivatives: Versatile and sustainable bio-resources for healthcare. Your body also needs the proper amount of vitamin C, zinc, copper and manganese to make the triple helix. A number of diseases are associated with collagen abnormalities or damage. 6368. Sources and formats of collagen for wound healing applications. Govindaraju P., Todd L., Shetye S., Monslow J., Pur E. CD44-dependent inflammation, fibrogenesis, and collagenolysis regulates extracellular matrix remodeling and tensile strength during cutaneous wound healing. Like a rope, which has several levels of coiling, the collagen fibril has four structural levels of which at least three are coils. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. Simultaneously, collagen degradation releases fragments that promote fibroblast proliferation and synthesis of growth factors that lead to angiogenesis and re-epithelialization. Among the top three formats used in the context of skin health and wound healing are matrices, dietary supplements and sponges with antimicrobials incorporated. Originariamente lo chiam "zucchero di gelatina", ma il chimico francese Jean-Baptiste Boussingault dimostr che conteneva azoto. 2018;31(5):1943-1949. This population study evaluated 4,109 people who had elective coronary angiography to diagnose stable angina (a blockage in the coronary artery). Amino acids are the building blocks of proteins; therefore, it is no surprise that collagen is comprised of amino acids. Vitamin C deficiency slows the production of hydroxyproline and stops the construction of new collagen, ultimately causing scurvy. 2012;3:61. doi:10.3389/fneur.2012.00061. Collagen in all its forms, triple-helical, matrix-incorporated and degraded fragments, are cognate ligands of diverse families of cell surface receptors including integrins, receptor tyrosine kinases and immunoglobulin type receptors [1,39]. This article tells you. These differences have been attributed to the amino acid (particularly glycine, proline and hydroxyproline) content of the collagen I [69]. It is also available in supplement form. Composites of collagen with silk fibroin, alginate and other polymers were also noted. Certain ingredients could pose health risks, such as herbs and high levels of vitamins in supplements formulated to support the health of the skin, nails, and hair (29). Whether youre fighting off an infection or combating a cold, adding a Other double-blind, placebo-controlled studies. Make sure that you get your powder from grass-fed, pasture-raised cows (with no antibiotics or chemicals). These foods contain the amino acids proline and glycine. What you eat affects many aspects of health including your skin. Here are 12 foods and beverages to add to your diet for better skin health. As the amount of collagen in your body decreases with age, your risk of degenerative joint disorders such as osteoarthritis increases (7). These can be acquired or caused by a genetic mutation. They were then given 3 grams of glycine or a placebo 30 minutes before bed. The 18 Best Protein Sources for Vegans and Vegetarians, Top 6 Benefits of Taking Collagen Supplements, cellular migration, a process necessary for tissue maintenance, bones, skin, and ligaments of animals, such as chicken skin and pig knuckle, certain types of seafood, such as fish skin and jellyfish, products made from animal parts such as bones and ligaments, including. Collagen III is the first to be synthesized in the early stages of wound healing and is replaced by collagen I, the dominant skin collagen. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. Extracellular Matrix Reorganization during Wound Healing and Its Impact on Abnormal Scarring. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. The structure of SC is like a brick wall, in which the corneocytes or bricks are surrounded by the intercellular lipid lamellae that act like the mortar to maintain both SC integrity and skin permeability barrier [].The skins barrier function depends mainly on the integrity of the SC. Collagen I is known to potently stimulate angiogenesis in vitro and in vivo through engagement of specific integrin receptors. Seafood Check out our roundup of the best collagen supplements. Degradation is regulated by extracellular and intracellular pathways. Most people who experience negative side effects from collagen either went over recommended dosages or have pre-existing allergies. However, there has been little research on long-term use. Good sources of glycine-rich foods include legumes, fish, dairy, and meat. Lo scienziato americano Eben Norton Horsford, propose il nome glicocolla; tuttavia, il chimico svedese Jns While the study is promising, research on the topic is limited. Because your skin is now thinner, cellulite becomes more evident no more hiding whats happening below the surface. All collagen contains 19 different amino acids, with a particularly high content of hydroxyproline, glycine, and proline. Healthcare providers sometimes prescribe glycine to people who have just had an ischemic stroke. In addition to improving some aspects of skin health and appearance, collagen supplements may offer a few other benefits. Main Benefits: Soothe skin, help moisturize, act as antioxidants. In this work the significance of collagen in different biological processes relevant to wound healing are reviewed and a summary of the current literature on the use of collagen-based products in wound care is provided. Collagen contains 22 30% glycine. Glycine is believed to be important for joint, bone, and tissue strength. Type I collagen is one of the most abundant molecules in the body, and it is particularly important in bone, skin, and connective tissue. Kisling A., Lust R.M., Katwa L.C. Research shows that taking hydrolyzed collagen reduces joint pain after exercise and boosts the density of your cartilage, making joints more flexible. We've updated our Privacy Policy, which will go in to effect on September 1, 2022. 2004;55(2):165-171. doi:10.1016/s0006-3223(03)00707-8, Hahn RG. Who Should Use It: In general, whatever amino acids are added to your skincare will be catered to the function of the product.. How Often Can You Use It: You can use amino acids as often as you want; they are gentle enough for everyday use. HC in electrospun nanofibrous scaffolds was shown to have biomechanical and antimicrobial properties [81,110]. In a 2016 review of studies, researchers found conflicting evidence about glycine's effect on schizophrenia. It is most well-known for the structural role it plays in the body. This kind of regular repetition and high glycine content is found in only a few other fibrous proteins, such as silk fibroin (75-80% Gly and Ala + 10% Ser). It is most well-known for the structural role it plays in the body. The risks associated with the use of animal sources of collagen can be overcome by the use of alternatively sourced collagen. Collagens are a structural component of the ECM that contribute to skin flexibility in addition to stabilizing growth factors and regulating cell adhesion and signaling between cells and ECM. Collagen is a major structural protein, forming molecular cables that strengthen the tendons and resilient sheets that support the skin and internal organs. Collagen is found in connective tissue, skin, tendon, bone, and cartilage and has many functions. Interestingly, HC has antioxidant and antimicrobial activities. Collagen provides structure to our bodies, protecting and supporting the softer tissues and connecting them with the skeleton. In recent years interest in collagen nanostructures has surged [78]. Thats valuable glycine. AJOG's Editors have active research programs and, on occasion, publish work in the Journal. However, there is still a need for high-quality studies and randomized control trials to support their clinical applications [46,75]. Glycine played a role in maintaining the health of mice suffering from osteoarthritis . To slow the effects of skin aging, wear sunscreen every day. It is one of the most plentiful proteins present in mammals and it is responsible for performing a variety of important biological functions. For example, smoking cigarettes is known to degrade collagen and cause skin aging, wrinkles, and loss of elasticity (12, 13). Glycine toxicity from supplements is rare. Schultz G., Chin G., Moldawer L., Diegelmann R. Barnes M. Update on Collagens: What You Need to Know and Consider. Type of Ingredient: Varying. Natural 3D-Printed Bioinks for Skin Regeneration and Wound Healing: A Systematic Review. Collagen dressing formats for wound healing clinical studies. Accessibility It also forms blood vessels and tissue within the heart. All rights reserved. Feng X., Tonnesen M.G., Mousa S.A., Clark R.A.F. Collagen is a major component of your skin. Main Benefits: Soothe skin, help moisturize, act as antioxidants. Felician F.F., Xia C., Qi W., Xu H. Collagen from Marine Biological Sources and Medical Applications. Our team aims to be not only thorough with its research, but also objective and unbiased. In addition, unless instructed by a healthcare provider, the following people should avoid glycine: It is essential to carefully read the ingredient list and nutrition facts panel of a supplement to know which ingredients and how much of each ingredient is included. In this structure, the researchers placed a larger alanine amino acid in the position normally occupied by glycine, showing that it crowds the neighboring chains. Glycine supplements are generally considered safe if used as directed. As these inedible animal parts simmer for hours or days, they release collagen in an easy-to-absorb broth. Additionally, following a diet high in added sugar and ultra-processed foods can lead to premature aging by contributing to a process called glycation, which reduces collagen turnover and interferes with collagens ability to interact with surrounding cells and proteins (14). de Paz-Lugo P, Lupiez JA, Melndez-Hevia E. High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis. Glycine is important because it: Glycine may also benefit the following, though evidence is limited and more research is needed: Unlike some amino acids that must be obtained solely through foods, the body can produce glycine. The heads bind strongly together, head-to-head, and four collagen molecules associate together through their tails, forming an X-shaped complex. Therefore, some researchers have looked at the connection between glycine and heart disease. Emerging and innovative approaches for wound healing and skin regeneration: Current status and advances. By James Myhre & Dennis Sifris, MD Try this today: Although collagen supplements differ in ingredients and collagen type, a product that contains types I and lll collagen fibers will cover most of your bases, no matter what your goal for supplementing. Liu X., Zheng C., Luo X., Wang X., Jiang H. Recent advances of collagen-based biomaterials: Multi-hierarchical structure, modification and biomedical applications. Healthline Media does not provide medical advice, diagnosis, or treatment. The most common is oral gel caps, typically available in 500 milligrams (mg) to 1,000 mg doses. The resolution of inflammation in a timely manner is equally important in normal wound healing. Collagen is composed mainly of the amino acids glycine, proline, and hydroxyproline. The collagen helix shown on the right contains a segment of human collagen. Targeting glutamate to treat schizophrenia: lessons from recent clinical studies. A structural protein is one that makes up the structure or framework of your cells and tissues (1). Your body naturally produces collagen, and you can consume it through dietary sources such as chicken skin and fish skin as well as collagen supplements. [(accessed on 24 April 2021)]; https://creativecommons.org/licenses/by/4.0/, https://www.ncbi.nlm.nih.gov/books/NBK507709/, https://www.biospace.com/article/collagen-dressings-market-exceptional-biological-properties-of-collagen-dressings-to-fuel-market-growth/, https://www.marketsandmarkets.com/Market-Reports/wound-dressings-market-123903496.html, Composites (e.g., silk fibroin, alginate). A search of clinicaltrials.gov using the criteria (collagen + skin + wound) identified 45 clinical studies. Salvatore L., Gallo N., Natali M.L., Campa L., Lunetti P., Madaghiele M., Blasi F.S., Corallo A., Capobianco L., Sannino A. The site is secure. If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password They have been used as matrices/scaffolds for tissue engineering, hemostatics, soft tissue repair and more recently as a drug delivery system [6,10,11,26,53,72,73,74,75,76,77,78,79,80]. (https://pubmed.ncbi.nlm.nih.gov/32009486/). Defects in the regulated turnover of collagens results in pathological conditions such as fibrosis [20,30,31,32]. Smoking cigarettes and drinking excessive amounts of alcohol negatively affect collagen production, as does following a diet high in ultra-processed foods and added sugar (12, 13, 14). You can take it as a supplement or add it to beverages both hot and cold and foods such as oatmeal, yogurt, and energy balls. The debate around the usefulness of collagen supplements continues. Although several foods contain collagen, its unknown whether these foods offer the same benefits as supplements. Animal products, like eggs, poultry, fish and milk, can all help boost collagen formation. government site. Even though the research is promising, experts caution that stronger evidence is still needed before recommending collagen as a treatment for osteoarthritis. In turn, this may lead to lower inflammation, better joint support, and reduced pain (10). Studies have even found that glycine can be used to help reduce alcohol-induced liver damage and other forms of acute or chronic liver injury. For example, in a 2011 study in Psychiatry and Clinical Neurosciences, researchers measured serotonin levels in rats after glycine administration. Garca-Coronado JM, Martnez-Olvera L, Elizondo-Omaa RE, et al. Your bones are made mostly of collagen, which gives them structure and strength (11). Excessive sun exposure degrades collagen production as well, so wearing sunscreen and avoiding excessive sun exposure can help prevent signs of premature skin aging (15). Dear Friends and Colleagues, As Editor-in-Chief of Metabolism: Clinical and Experimental, I'm happy to share great news about the journal. Elgharably H., Roy S., Khanna S., Abas M., Dasghatak P., Das A., Mohammed K., Sen C.K. Electrospun PCL/PLA Scaffolds Are More Suitable Carriers of Placental Mesenchymal Stromal Cells Than Collagen/Elastin Scaffolds and Prevent Wound Contraction in a Mouse Model of Wound Healing. Studies show that taking collagen seems to be particularly helpful for certain purposes and populations, including for increasing bone mineral density (BMD) in people in postmenopause who have low BMD. In the skin, the fibrillar collagens types I, III and V are the most common, followed by fibril-associated collagens type XII, XIV, XVI, and VI. Thats valuable glycine. It even helps their bodies manage difficult-to-digest foods better long term by helping repair parts of the GI tract. Guo S., Dipietro L.A. Factors affecting wound healing. This bad taste will go away in a few minutes, but it can usually be avoided altogether by taking the powder in a smoothie, for example. There are 28 types of collagen, but here are the four most common (1): In recent years, collagen supplements have become popular. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Then, when this denatured mass of tangled chains cools down, it soaks up all of the surrounding water like a sponge, forming gelatin. Works Well With: Pretty much Type I collagen is one of the most abundant molecules in the body, and it is particularly important in bone, skin, and connective tissue. Hydroxylation and glycosylation of amino acid residues results in the formation of the triple-helical structure characteristic of collagens. Join over 22,000 learners who have passed their exams thanks to us! Hong H., Fan H., Chalamaiah M., Wu J. If you're ready to pass your A-Level Biology exams, become a member now to get complete access to our entire library of revision materials. Bhardwaj N., Chouhan D., Mandal B.B. More research is needed to determine whether eating collagen-rich foods helps increase collagen levels in your body, as they may not have the same benefits as supplements. You can also use collagen in recipes for your family or kids, such as homemade healthy jello or all-natural fruit snacks. Marcos-Garcs V., Molina Aguilar P., Bea Serrano C., Garca Bustos V., Benavent Segu J., Ferrndez Izquierdo A., Ruiz-Saur A. Age-related dermal collagen changes during development, maturation and ageingA morphometric and comparative study. The production of constructs for large wound areas is a challenge. Hydrolyzed collagen is a common type of collagen used in supplements that is created using a process called hydrolysis. Last medically reviewed on September 21, 2022. Type III Collagen is a homotrimer, or a protein composed of three identical peptide chains (), each called an alpha 1 chain of type III collagen.Formally, the monomers are called collagen type III, alpha-1 chain and in humans are encoded by the COL3A1 gene.Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain. Glycine is one of the hardest ingredients for vegans to get from their diet. Hydroxyproline, which is critical for collagen stability, is created by modifying normal proline amino acids after the collagen chain is built. An official website of the United States government. Several studies are in the actively recruiting stage. These fragments specifically guide blood vessel pruning that in turn enables the re-establishment of the tissue architecture during healing [23,35,36,37,38]. Psychiatry Clin Neurosci. Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. [(accessed on 20 April 2021)]; MarketsandMarkets Wound Dressings Market by Type (Traditional, Advanced (Alginate, Collagen, Hydrogel, Foam, Hydrocolloid, Film)), Wound Type (Traumatic, Surgical, Diabetic Foot, Venous Leg Ulcer & Burns), End User (Hospital, ASCs, Homecare)Global Forecast to 2025. Collagen wound dressings contain collagen blended with natural and synthetic polymers such as polyethylene oxide, poly (L-lactic acid), hyaluronic acid, elastin and silk fibroin, alginate, chitosan, etc [73,81,82,83,84,85]. Those who received glycine had significantly decreased wakefulness and increased non-rapid-eye-movement (NREM) sleep during the first 90 minutes compared with the control group. 2015 Apr;145(4):720-8. doi:10.3945/jn.114.201293. These findings suggest that taking collagen supplements long-term may help increase bone mineral density in people in postmenopause, who are at a greater risk of developing osteopenia and osteoporosis.

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